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. 2018 Jan 23;19(2):330. doi: 10.3390/ijms19020330

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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B2R signaling inhibition reduces pathological vessels in Oxygen-induced retinopathy (OIR) model. Representative OIR flat mounted retinas stained for IB4-488: (a) vehicle treated and (c) fasitibant treated. Left panels: magnification 4×, scale bar = 100 µm; Right panels: magnification 40×; (b) quantification of avascular area and (d) area with neovascular tufts. The extent of neovascular tufts area was quantitatively evaluated outlining with Photoshop the border of tufts between the vascularized peripheral area and the avascular central area and the density of neovascular tufts area was quantified by ImageJ software. Each column represents the mean ± SD of data from 10 different quadrants derived from 10 retinas. ** p < 0.01 vs. Ctr.

B2R signaling inhibition reduces pathological vessels in Oxygen-induced retinopathy (OIR) model. Representative OIR flat mounted retinas stained for IB4-488: (a) vehicle treated and (c) fasitibant treated. Left panels: magnification 4×, scale bar = 100 µm; Right panels: magnification 40×; (b) quantification of avascular area and (d) area with neovascular tufts. The extent of neovascular tufts area was quantitatively evaluated outlining with Photoshop the border of tufts between the vascularized peripheral area and the avascular central area and the density of neovascular tufts area was quantified by ImageJ software. Each column represents the mean ± SD of data from 10 different quadrants derived from 10 retinas. ** p < 0.01 vs. Ctr.