Figure 5.

BK/B2R signaling inhibits proangiogenic growth factor expression in OIR mice. (a) representative blots of fibroblast growth factor (FGF-2), vascular endothelial growth factor (VEGF), hypoxia inducible factor (HIF(-1α and B2R expression in OIR mice treated with or without fasitibant (fas) given at 2 mg/kg. Two groups of fasitibant 2 mg/kg are reported in which each lane is representative of four pooled retinas (b) lane quantification with ImageJ. Data are reported as arbitrary density unit (A.D.U.). FGF-2, VEGF, HIF-1α and B2R lanes were normalized to β-actin. Fas bands are the mean of the two representative groups (8 retinas) reported in panel (a). * p < 0.05; *** p < 0.001 vs. Ctr.