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. 2018 Jan 24;19(2):341. doi: 10.3390/ijms19020341

Figure 5.

Figure 5

Figure 5

Effects of erinacine A-enriched Hericium erinaceus mycelium on hippocampal protein expressions of BDNF, TrkB and PI3K signaling pathways in repeated restraint-stressed mice. (A) Western blots of BDNF, TrkB, PI3K signaling pathways and β-actin; (B) Densitometric analyses of (A), presented as the relative ratio of each protein to β-actin. Values are means ± SEM of three independent experiments. Con: normal control mice, RS: mice received vehicle treatment followed by repeated restraint stress, RS + HEL: mice received low dose of HE (100 mg/kg body weight) treatment followed by repeated restraint stress, RS + HEM: mice received middle dose of HE (200 mg/kg body weight) treatment followed by repeated restraint stress, RS + HEH: mice received high dose of HE (400 mg/kg body weight) treatment followed by repeated restraint stress. * p < 0.05; ** p < 0.01 and *** p < 0.001 vs. the Con group; ## p < 0.01 and ### p < 0.001 vs. RS group. Significant differences between groups were determined using one-way ANOVA and Tukey’s post-hoc test.