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. 2018 Jan 24;19(2):342. doi: 10.3390/ijms19020342

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Results of qPCR analysis of Cnr1 (A); Cnr2 (B); Trpv1 (C); and Faah (D); gene expression levels in the dorsal part of the lumbar spinal cord after MIA injection and treatment with OMDM198, SB366791 or URB597. Samples were collected 21 days after MIA injection, 1 h after i.p. administration of OMDM198, SB366791, URB597 or vehicle. Data are presented as the mean ± SEM and represent normalized averages derived from 6–10 samples for each group. The results are presented as a fold change normalized to the expression of the reference gene Hprt1 compared to the intact animals. Statistical analysis was performed using one-way ANOVA followed by Bonferroni post hoc tests. Values with p < 0.05 were considered significant. * Denotes significant differences vs. intact; # denotes significant differences vs. the same side of the vehicle-treated osteoarthritic animals. **, ***, **** denote higher significance levels.

Results of qPCR analysis of Cnr1 (A); Cnr2 (B); Trpv1 (C); and Faah (D); gene expression levels in the dorsal part of the lumbar spinal cord after MIA injection and treatment with OMDM198, SB366791 or URB597. Samples were collected 21 days after MIA injection, 1 h after i.p. administration of OMDM198, SB366791, URB597 or vehicle. Data are presented as the mean ± SEM and represent normalized averages derived from 6–10 samples for each group. The results are presented as a fold change normalized to the expression of the reference gene Hprt1 compared to the intact animals. Statistical analysis was performed using one-way ANOVA followed by Bonferroni post hoc tests. Values with p < 0.05 were considered significant. * Denotes significant differences vs. intact; # denotes significant differences vs. the same side of the vehicle-treated osteoarthritic animals. **, ***, **** denote higher significance levels.