Table 1.
Suppression of ESX-3 core genes and associated genes by IdeR, Zur and MntR.
| Gene | IdeR | Zur | MntR |
|---|---|---|---|
| esx3-operon 1 | − | − | − |
| esxG-esxH | − | − | − |
| esxQ | − | ||
| esxR-esxS | − | − | |
| esxW | − | ||
| ppe3 | − | − | |
| ppe4-pe5 | − | − | − |
| ppe9 | + | ||
| pe13 | 2 | − | |
| ppe19 | − | ||
| ppe20 | − | ||
| ppe37 | − | ||
| ppe38 | 2 | ||
| ppe48 | − | ||
| pe_pgrs61 | − |
Plus symbols (+) indicate positive regulation, while minus symbols (−) indicate negative regulation. 1 Rv0282-Rv291; 2 Reported as Zur regulated by Maciag et al. based on direct experimental evidence on two conditions [22]; predicted not to be in the Zur regulon through a large scale analysis of transcriptomics datasets and analysis of binding sites in upstream sequences [99].