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Integration of bone morphogenic protein (BMP) and wingless and int-1 (Wnt) signaling pathways, miRNAs, and key transcription factors in regulating osteoblast and adipocyte differentiation of MSCs. The BMP signaling, Wnt signaling, and miRNAs regulate osteoblast differentiation or adipocyte differentiation of MSCs by targeting key transcription factors such as runx2, osterix, or PPARγ.
