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Domain regions and organizational structure of plakin proteins. CH-ABD: calponin homology actin-binding domain; SR: spectrin repeats; EFH: EF-hand calcium-binding domain; GAS2-MTBD—growth-arrest specific protein 2 microtubule binding domain; Plec: plectin; SBCC: DNA repair exonuclease SbcCD ATPase subunit domain; PD: Plectin domain; Cast: RIM-binding protein of the cytomatrix active zone; Smc: Chromosome segregation ATPase; SCP: Synaptonemal complex protein 1.
