Table 1.

Diseases and disorders associated with plakin proteins.

Plakin Family Member	Associated Diseases and Disorders	Refs.
MACF1	Neuromuscular disease, Parkinson’s disease, cancer	[29,30,31,32,33,34,35]
BPAG1	paraneoplastic pemphigus, pemphigus foliaceus, erythema multiforme, mucosal-dominant pemphigus vulgaris, multiple sclerosis, dystonia musculorum	[36,37,38,39,40,41,42]
Desmoplakin	paraneoplastic pemphigus, pemphigus foliaceus, erythema multiforme, mucosal-dominant pemphigus vulgaris, cardiomyopathy, cancer	[37,38,39,43,44,45,46,47,48,49,50,51,52]
Envoplakin	paraneoplastic pemphigus	[53,54]
Periplakin	paraneoplastic pemphigus, cancer	[53,54,55,56]
Plectin	epidermolysis bullosa simplex, cancer	[57,58]