Table 1.

A description of annotated metabolites that differed significantly between the two patient groups and were sensitive (responders) or insensitive (non-responders) to the in vitro antiproliferative effect of phosphatidylinositol-3-kinase-Akt-mechanistic/mammalian target of rapamycin (PI3K-Akt-mTOR) inhibition.

Metabolite	p-Value	Ratio * Responder versus Non-Responder	Short Description
↓Allose	0.037	−0.875	Sugar metabolism. Possibly involved in cell cycle regulation.
↓Citric acid	0.005	−1.262	Energy metabolism, citric acid cycle.
↓Cysteinyl-cysteine	0.006	−1.471	Dipeptide
↓Glutamine	0.029	−0.737	Non-essential amino acid, important for nucleic acid synthesis. Energy metabolism, conditionally essential during catabolic states.
↓Indoleacrylic acid	0.047	−0.426	Involved in tryptophan metabolism.
↓Isocitric acid	0.029	−0.698	Substrate of the citric acid cycle.
↑Phosphatidyl inositol (18:0/0:0)	0.040	0.765	Lipid metabolism, cell membrane constituents.
↑Phosphatidyl inositol (15:1(9Z)/22:6(4Z,7Z,10Z,13Z16Z19Z))	0.025	0.809	Lipid metabolism, cell membrane constituents.
↓Phosphonic acid (8:0/8:0)	0.009	−1.660	Lipid metabolism
↓Proline	0.046	−0.611	Non-essential amino acid, synthesized from glutamic acid and also other amino acids, energy metabolism.
↓Taurine	0.035	−1.0524	Sulfur amino acid not incorporated into protein; adults can synthesize taurine from cysteine. Stabilizes cell membranes, regulates ion transport.
↓2-amino-4-hydroxy-propiophenone	0.021	−0.744	Lipid metabolism
↓4-phenyl-1,2,3-thiadiazole	0.041	−1.024	Inhibitor of cytochrome P450 enzymes that regulate arachidonic acid metabolism.
↓4,7,10,13-eicosatetraenoic acid	0.021	−0.983	Arachidonic acid metabolite, possibly influencing the leukotriene B4 (LTB4) pathway; expression of the LTB4 receptor (BLT1) may be altered in myeloid leukemia cells.
↓4,7,10,13,16-docosapentaenoic acid	0.042	−0.766	Fatty acid and arachidonic acid metabolism, an intermediate between eicosapentaenoic acid and docosahexaenoic acid, precursor of prostanoids that are only formed from docosapentaenoic acid.

* Responders versus non-responders were compared as the log₂-ratio. The arrows to the left in the table indicate whether the mean metabolite levels were decreased (↓) or increased (↑) in responder cells relative to the non-responder cells. The information in this table is based on PubChem and Human Metabolome databases.