Table 2.

Important clinical and biological characteristics of responders and non-responders to of phosphatidylinositol-3-kinase- mechanistic/mammalian target of rapamycin (PI3K-mTOR) inhibitors.

ID	Gender	Age	Previous Hematological Malignancy or Chemotherapy	FAB	CD34	Karyotype		Flt3 Mutation	NPM-1 Mutation
						Abnormality	Classification
Responders
1	F	45	Chemotherapy	M4	Negative	Normal	Normal	wt	ins
2	F	63		M4	Positive	Normal	Normal	ITD	wt
3	M	72		M5	Negative	Normal	Normal	wt	ins
4	M	29	Relapse	M4	Positive	Normal	Normal	ITD	ins
5	F	80		M2	Positive	Complex	Adverse	wt	wt
6	F	36		M4	Positive	Normal	Normal	wt	nt
7	F	75		M1	Positive	nt		ITD	wt
8	M	71	Relapse	M2	Negative	Normal	Normal	G835
9	M	35		M2	Positive	Normal	Normal	wt	wt
10	M	72	Myelodysplastic syndrome	M1	Positive	Complex	Adverse	wt
11	F	64	Chemotherapy	M2	Negative	Normal	Normal	ITD	ins
12	F	59	Chemotherapy	M5	Negative	Normal	Normal	ITD	ins
13	M	58		M5	Positive	Normal	Normal	wt	wt
14	F	59	Chemotherapy	M4	Negative	Normal	Normal	ITD	ins
15	F	75		M4	Positive	Normal	Normal	ITD	wt
Non-responders
16	F	29	Chemotherapy	M5	Positive	Normal	Normal	ITD+Asp835	wt
17	M	24		M2	Positive	Multiple	Adverse	nt	wt
18	F	82		M4	Positive	Normal	Normal	ITD	wt
19	F	77		M1	Negative	nt		nt	ins
20	M	84		M1	Positive	Multiple	Adverse	wt	wt
21	M	53		M0	Positive	13	Intermediate	wt	wt
22	M	65		M5	Negative	Normal	Normal	ITD	ins
23	F	46		M1	Positive	inv(16)	Favorable	wt	wt
24	F	70		M4	Negative	nt		wt	ins
25	M	33	Chemotherapy	M1	Positive	Normal	Normal	wt	wt
26	F	77		M1	Positive	nt		nt	wt
27	M	76		M0	Positive	Normal	Normal	wt	wt
28	M	60		M4	Positive	Normal	Normal	ITD	wt
29	M	36		M5	Positive	+8, +22, inv(16)	Favorable	ITD	wt
30	F	67		M5	Negative	t(9,11), +19	Intermediate	wt	wt

The table shows the gender (M, male; F, female) and age (years) of the individual patients at diagnosis. The FAB classification was used to classify morphological and/or histochemical signs of differentiation. Cytogenetic abnormalities were classified according to the medical research council (MRC) criteria. The detection of Fms like tyrosine kinase 3 (Flt3) (ITD, internal tandem duplications) or nucleophosmin (NPM)-1 insertions (ins) is also indicated in the table. Complex karyotype means at least three abnormalities [1]. FAB: The French-American-British (FAB) classification system; nt: not tested; wt: wild type.