cGMP |
current Good Manufacturing Practice(s) |
CHO |
Chinese Hamster Ovary |
gln |
glutamine |
gluc |
glucose |
GS |
Glutamine Synthetase |
GS-CHO |
Glutamine Synthetase transfected Chinese Hamster Ovary |
HIPDOG |
HI-end pH-controlled Delivery of Glucose |
IVCD |
integrated viable cell days |
LA |
lactate adapted cells |
Lac |
lactate |
Lac A |
lactic acid |
Laci
|
initial lactate |
LC |
lactate consumption |
LSA |
Lactate Supplementation and Adaptation |
NH4+
|
ammonium |
OA |
osmolality adapted cells |
NR |
not reported |
P |
nutrient or metabolite |
qGln |
specific glutamine uptake rate in μmol/106 cells-h |
qGluc |
specific glucose uptake rate in μmol/106 cells-h |
qLac |
specific lactic acid production rate in μmol/106 cells-h |
qNH4+ |
specific ammonium production rate in μmol/106 cells-h |
TCA |
tricarboxylic acid |
TCD |
Total Cell Density |
VCD |
Viable Cell Density |
Yl/g |
lactate produced per glucose consumed (mole/mole) |
Kd |
specific death rate in h−1
|
μN |
specific net growth rate in h−1
|
μT |
specific total growth rate in h−1
|