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. 2018 Jan 30;19(2):410. doi: 10.3390/ijms19020410

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The common model of PUF protein influences mRNA stability. (A) Some genes regulate the expression or binding efficiency of PUF proteins in nucleus and/or in cytoplasm; (B) The PUF protein can bind to the PUF binding motif, which is located in the 3′UTR of target gene, and recruit the CCR4-POP2-NOT complex through interacting with Pop2 (the subunit of CCR4-POP2-NOT complex). The CCR4-POP2-NOT complex acts as a deadenylase in cell. It can affect the mRNA stability by reducing the length of poly(A) tail. Meanwhile, Dhh1p (DExD/H-box ATP-dependent RNA helicase), which can interact with CCR4-POP2-NOT complex, acts on the cap to activate decapping and inhibit translation [60].