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cAMP-PKA pathway. (a) Signalling in a juxtaglomerular cell in absence of 1,25(OH)2-vitamin D3; (b) Signalling in presence of 1,25(OH)2-vitamin D3. cAMP: cyclic adenosine monophosphate, CBP: CREB-binding protein, CRE: cAMP-dependent response element, CREB: cAMP response element-binding protein, GαS: GS-protein alpha subunit, P: phosphate, PKA: protein kinase A, Pol II: RNA polymerase II, VDR: vitamin D receptor. The “+” stands for “JG in presence of”.
