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Structures of some synthetic analogues with proven biological effects related to dementia. SMDD (25) is a caffeic acid dimer that does not involve an ester bond but rather a C-C bridge. The C-5 chain derivative, compound 26, was found to have an optimum structure in antioxidant and Aβ aggregation inhibition studies from studies on derivatives including C-3 to C-9 chain length, while compound 27 was a prototype lead compound that does not have an ester linkage.
