Table 1.
Chemokine receptors expressed on neutrophils and their human and murine ligands 1.
| Receptor | Human Ligand(s) | Murine Ligand(s) |
|---|---|---|
| CXCR1 | CXCL6, CXCL8 | CXCL6 |
| CXCR2 | CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, CXCL8 | CXCL1, CXCL2, CXCL3, CXCL6, CXCL7 |
| CXCR3 | CXCL4, CXCL4L1, CXCL9, CXCL10, CXCL11, | CXCL4, CXCL9, CXCL10, CXCL11 |
| CXCR4 | CXCL12 | CXCL12 |
| CCR1 | CCL3, CCL3L1, CCL4L1, CCL5, CCL7, CCL8, CCL14, CCL15, CCL16, CCL23 | CCL3, CCL5, CCL6, CCL7, CCL9 |
| CCR2 | CCL2, CCL7, CCL8, CCL13, CCL16 | CCL2, CCL7, CCL12 |
| CCR3 | CCL3L1, CCL5, CCL7, CCL8, CCL11, CCL13, CCL15, CCL24, CCL26, CCL28 | CCL5, CCL7, CCL9, CCL11, CCL14, CCL24, CCL26, CCL28 |
| CCR5 | CCL3, CCL3L1, CCL4, CCL4L1, CCL5, CCL8, CCL11, CCL14, CCL16 | CCL3, CCL4, CCL5 |
| ACKR2 | Inflammatory CC chemokines | Inflammatory CC chemokines |
1 CXCR1 and CXCR2 are highly expressed on circulating neutrophils, CXCR4 is enhanced on “aging” neutrophils and other chemokine receptors may be upregulated on neutrophils in inflamed tissues.