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. 2018 Feb 6;19(2):472. doi: 10.3390/ijms19020472

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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HOXA11 mediates the effect of HOTTIP on breast cancer pathogenesis. (A): Cell Counting Kit 8 (CCK-8) assay showed that HOXA11 overexpression could rescue the effect of HOTTIP/HOXA11 knockdown on MCF-7 cell proliferation. (B): Plate colony formation assay showed HOXA11 overexpression could rescue the effect of HOTTIP/HOXA11 knockdown on MCF-7 cell colony formation. (C): Quantitative results of MCF-7 cell colony formation in Figure 4B. (D): Flow cytometry showed HOXA11 overexpression could rescue the effect of HOTTIP/HOXA11 knockdown on MCF-7 cell apoptosis. (E): In vitro wound healing experiment showed HOXA11 overexpression could rescue the effect of HOTTIP/HOXA11 knockdown on MCF-7 cell migration; the figures of the wound healing experiment at 0 h, 24 h, and 72 h in MCF-7 cells are shown. (F): Quantitative results of the wound healing experiment in Figure 4E. * p < 0.05. Scale bar represents 50 μm.

HOXA11 mediates the effect of HOTTIP on breast cancer pathogenesis. (A): Cell Counting Kit 8 (CCK-8) assay showed that HOXA11 overexpression could rescue the effect of HOTTIP/HOXA11 knockdown on MCF-7 cell proliferation. (B): Plate colony formation assay showed HOXA11 overexpression could rescue the effect of HOTTIP/HOXA11 knockdown on MCF-7 cell colony formation. (C): Quantitative results of MCF-7 cell colony formation in Figure 4B. (D): Flow cytometry showed HOXA11 overexpression could rescue the effect of HOTTIP/HOXA11 knockdown on MCF-7 cell apoptosis. (E): In vitro wound healing experiment showed HOXA11 overexpression could rescue the effect of HOTTIP/HOXA11 knockdown on MCF-7 cell migration; the figures of the wound healing experiment at 0 h, 24 h, and 72 h in MCF-7 cells are shown. (F): Quantitative results of the wound healing experiment in Figure 4E. * p < 0.05. Scale bar represents 50 μm.