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Regulation of hTERT transcription by 5-aza-2′-deoxycytidine. In cancer cells, CTCF recognition sequence in hTERT gene is hypermethylated, thus blocking CTCF binding and inducing hTERT expression. Treatment with 5-aza-2′-deoxycytidine leads to demethylation of hTERT promoter, thereby causing the binding of CTCF to the target site and suppressing hTERT transcription.
