Table 2.
Effect of delayed subculture and potentially lethal damage repair with SAHA treatment in A549 and AG1522 cells for different qualities of radiation. D10 values are mean ± standard error of the means.
| AG1522, D10 (Gy) | A549, D10 (Gy) | ||||
|---|---|---|---|---|---|
| SAHA Treatment Started Subculture Time after Irradiation | 24 h Before | 24 h Before | After Irradiation | ||
| 0 h | 24 h | 0 h | 24 h | 24 h | |
| γ-rays Control | 4.31 ± 0.41 | 6.35 ± 0.44 | 6.57 ± 0.37 | 8.43 ± 0.29 | NA |
| SAHA 0.2 μM | 4.49 ± 0.45 | 6.96 ± 0.36 | 6.01 ± 0.42 | 6.97 ± 1.13 | 8.77 ± 0.41 |
| SAHA 2 μM | 4.21 ± 0.73 | 7.02 ± 0.59 | 4.85 ± 0.95 | 6.15 ± 0.59 | 8.04 ± 0.24 |
| Proton SOBP Control | 3.90 ± 0.36 | 5.35 ± 1.30 | |||
| SAHA 0.2 μM | 3.78 ± 0.47 | 5.53 ± 1.90 | |||
| SAHA 2 μM | 2.81 ± 0.39 | 4.14 ± 0.89 | |||
| Carbon ion SOBP Control | 2.11 ± 0.75 | 3.09 ± 0.13 | |||
| SAHA 0.2 μM | 2.03 ± 0.25 | 2.93 ± 0.52 | |||
| SAHA 2 μM | 1.98 ± 0.06 | 2.57 ± 0.51 | |||
NA: Not Applicable.