Table 1.
Baseline characteristics of 44 patients with successful left atrial appendage closure and biomarker evaluation.
| Characteristic | Value |
|---|---|
| Demographics | |
| sex, male n (%) | 30 (68.2) |
| age, y (IQR) | 78 (75.8–83) |
| BMI, kg/m2 (IQR) | 28.1 (24.7–32.7) |
| Cardiovascular risk factors | |
| arterial hypertension, n (%) | 42 (95.4) |
| diabetes mellitus, n (%) | 16 (36.7) |
| HbA1c, % (IQR) | 7.0 (6.2–7.0) |
| hypercholesterinemia, n (%) | 22 (50) |
| cholesterol, mg/dL (IQR) | 143 (124–186) |
| low-density lipoprotein, mg/dL (IQR) | 89 (68–111) |
| high-density lipoprotein, mg/dL (IQR) | 55 (41–62) |
| triglycerides, mg/dL (IQR) | 117 (95–162) |
| impaired left ventricular function, each n (%) | |
| LVEF 45–54% | 4 (9.1) |
| LVEF 30–44% | 4 (9.1) |
| LVEF < 30% | 2 (4.5) |
| diastolic dysfunction, n (%) | 11 (25.0%) |
| combined with impaired left ventricular function, n (%) | 1 (2.3%) |
| Medical history | |
| atrial fibrillation, each n (%) | |
| Paroxysmal | 24 (54.5) |
| Persistent | 6 (13.6) |
| Permanent | 14 (31.8) |
| pulmonary vein isolation, n (%) | 4 (9.1) |
| transitory ischemic attack, n (%) | 3 (6.8) |
| stroke, n (%) | 7 (15.9) |
| coronary artery disease, n (%) | 25 (56.8) |
| myocardial infarction, n (%) | 10 (22.7) |
| heart failure, n (%) | 10 (22.7) |
| peripheral vascular disease, n (%) | 4 (9.1) |
| chronic kidney disease, n (%) | 18 (40.9) |
| chronic liver disease, n (%) | 3 (6.8) |
| sleep apnea, n (%) | 4 (9.1) |
| prior bleeding, n (%) | 34 (77.3) |
| CHA2DS2-VASc score (IQR) | 4 (3–5) |
| HAS-BLED score (IQR) | 4 (3–5) |
| Postinterventional antithrombotic regimen | |
| dual antiplatelet therapy for 6 months, n (%) | 44 (100.0) |
| Reasons for rehospitalization/severe clinical events during mid-term follow-up | |
| myocardial infarction, n (%) | 1 (2.3) |
| heart failure, n (%) | 6 (13.6) |
| arrhythmia, n (%) | 2 (4.5) |
| vascular problem, n (%) | 2 (4.5) |
| gastrointestinal bleeding, n (%) | 8 (18.2) |
| renal failure, n (%) | 1 (2.3) |
| infectious disease, n (%) | 2 (4.5) |
| orthopedic, n (%) | 2 (4.5) |
| Bleeding during mid-term follow-up, BARC-Score | |
| 1, n (%) | 1 (2.3) |
| 2, n (%) | 5 (11.4) |
| 3a, n (%) | 2 (4.5) |
| ≥3b, n (%) | 0 (0) |
The values are given as medians (25th and 75th percentiles) or total numbers (percentage); BARC = Bleeding Academic Research Consortium, BMI = body mass index, CHA2DS2-VASc = congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, prior stroke or TIA or thromboembolism, vascular disease, age 65–74 years, sex category (i.e., female sex), dL = deciliter, HAS-BLED = hypertension, abnormal renal or liver function, prior stroke, prior major bleeding or predisposition to bleeding, labile INR, elderly, i.e., age > 65 years, prior alcohol, drug, or medication usage predisposing to bleeding, IQR = interquartile range, LVEF = left ventricular ejection fraction, kg = kilogram, m = meter, mg = milligram, min = minute, mL = milliliter, pg = picogram, y = years.