Table 2.
Changes of patients’ characteristics over mid-term follow-up.
| Characteristics | T1 | T2 | p Value |
|---|---|---|---|
| Smoking status | |||
| never, n (%) | 37 (84.1) | 37 (84.1) | 1.000 |
| >1 year former, n (%) | 1 (2.3) | 1 (2.3) | 1.000 |
| current, n (%) | 6 (13.6) | 6 (13.6) | 1.000 |
| Pharmacotherapy | |||
| beta blockers, n (%) | 17 (38.6) | 15 (34.1) | 0.825 |
| calcium channel blockers, n (%) | 9 (20.5) | 7 (15.9) | 0.783 |
| combined therapy, n (%) | 14 (31.8) | 15 (34.1) | 1.000 |
| statines, n (%) | 27 (61.4) | 28 (63.6) | 1.000 |
| statin and ezetimibe, n (%) | 1 (2.3) | 1 (2.3) | 1.000 |
| other lipid-lowering drugs, n (%) | 1 (2.3) | 1 (2.3) | 1.000 |
| Anticoagulation | |||
| None | 15 (34.1) | 43 (97.7) | <0.001 |
| Any | 29 (65.9) | 1 (2.3) | <0.001 |
| phenprocoumon, n (%) | 10 (22.7) | 0 (0.0) | 0.001 |
| dabigatran, n (%) | 3 (6.8) | 0 (0.0) | 0.241 |
| rivaroxaban, n (%) | 3 (6.8) | 0 (0.0) | 0.241 |
| apixaban, n (%) | 3 (6.8) | 1 (2.3) | 0.616 |
| LMWH, n (%) | 10 (22.7) | 0 (0.0) | 0.001 |
| Echocardiographic data | |||
| LA diameter, mm (IQR) | 48.0 (43.7–55.0) | 49.0 (44.0–53.0) | 0.657 |
| LA surface, cm2 (IQR) | 24.0 (19.7–28.0) | 22.0 (19.0–25.0) | 0.010 |
| LA volume, cm3 (IQR) | 88.5 (70.2–105.3) | 83.0 (66.2–100.5) | 0.739 |
| Laboratory values | |||
| cholesterol, mg/dL (IQR) | 143 (124–186) | 155 (128–161) | 0.370 |
| NT-proBNP, pg/mL (IQR) | 975 (455–1429) | 981 (488–1852) | 0.323 |
| creatinine, mg/dL (IQR) | 1.10 (0.96–1.42) | 1.24 (1.01–1.71) | 0.430 |
| MDRD-GFR, mL/min/1.73 m2 (IQR) | 65 (43–65) | 56 (37–65) | 0.140 |
| Hb, g/dl (IQR) | 12.4 (10.7–14.5) | 10.8 (9.6–12.7) | 0.810 |
| anemia < 10 g/dL, n (%) | 8 (18.2) | 8 (18.2) | 1.000 |
| average blood glucose, g/dL (IQR) | 113 (94–133) | 108 (90–112) | 0.900 |
| CRP, mg/L (IQR) | 5.1 (2.9–11.1) | 4.0 (2.9–14.3) | 0.560 |
| LDH, U/L (IQR) | 198 (176–240) | 240 (199–253) | 0.930 |
The values are given as medians (25th and 75th percentiles) or total numbers (percentage); p values are based on a dependent Student’s t-test or the Fisher’s exact test before and after left atrial appendage closure, p < 0.05 indicates statistical significance; cm = centimeter, CRP = C reactive protein, dL = deciliter, g = gram, Hb = hemoglobin, L = liter, LA = left atrial, LDH = lactate dehydrogenase, LMWH = low-molecular-weight heparin MDRD = Modification of Diet in Renal Disease, mg = milligram, min = minute, mL = milliliter, mm = millimeter, NT-proBNP = amino-terminal pro-brain natriuretic peptide, pg = picogram, U = units.