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. 2018 Feb 12;19(2):557. doi: 10.3390/ijms19020557

Table 1.

Human papillomavirus (HPV), human immunodeficiency virus (HIV), p16, and Ki-67 status in esophageal squamous cell carcinoma (ESCC), dysplasia and histopathologically normal biopsies.

Study Number Hist. Diagn. 1 Grading Ki-67 Index Overall 2 p16INK4a Staining Pattern 3 p16INK4a Stained Tumor Cell Areas 4 % of Ki-67 Stained Cells within p16INK4a Stained Areas HPV qPCR 5 HPV ISH 6 HIV Status 7
HV090610-44 1 1 3 2 1 71 1 0 0
DV280610-68 1 1 3 1 2 88 1 0 0
EC070710-73 2 - 3 1 2 51 1 0 0
FN280710-105 1 1 3 1 2 67 1 0 -
AM240510-22 1 2 3 1 2 61 1 0 0
JS070710-72 1 1 3 1 2 72 1 0 0
MRD160610-57 1 2 - - - - 1 - 0
PD120510-1 1 2 3 0 0 - 0 0 0
CC050710-70 2 - 3 0 0 - 0 0 1
AM14071087 1 2 2 2 2 26 0 0 0
EK070610-40 1 2 3 0 0 - 0 - 0
SN210710-101 1 2 3 0 0 - 0 - -
SN210710-96 1 2 3 0 0 - 0 - -
HM070710-74 1 3 - - - - 0 - 0
LI190710-91 1 2 - - - - 0 - -
DM090610-41 1 2 3 1 2 60 0 - 0
AOM160610-55 1 2 3 1 2 53 0 0 0
MG260510-29 1 2 3 1 2 55 0 - 0
EO160610-59 1 3 3 1 1 60 0 - 0
LC150610-97 1 2 2 1 2 25 0 - -
LM180510-10 1 2 3 0 0 - 0 - 1
PL130710-81 1 2 2 1 2 46 0 0 0
RC170510-7 1 2 2 1 2 45 0 - 0
EM280610-69 2 - 3 1 2 67 0 - 0
LN180510-12 1 3 2 0 0 - 0 - -
ESL190510-17 1 3 2 1 2 48 0 - 0
JC260710-102 1 2 3 0 0 - 0 - -
DL160610-56 1 3 2 1 2 49 0 - 1
JC120510-2 1 2 3 0 0 - 0 - 0
JN140610-54 1 2 0 1 1 0 0 0 0
RM170510-8 1 2 2 1 2 47 0 - 0
ZV160610-58 1 2 3 1 1 62 0 - 0
SF270710-103 1 - 2 0 0 - 0 - -
FM140710-86 1 3 3 1 2 54 0 - 0
OD120510-3 1 2 2 1 2 45 0 - 0
DK280610-66 1 3 3 1 1 78 0 - 0
MJ020610-34 1 3 2 0 0 - 0 - 1
JK140710-89 1 2 3 1 2 65 0 - 0
RM210710-93 1 2 3 0 0 - 0 - -
AM140710-84 1 3 3 0 0 - 0 - 0
BZ020610-35 1 2 0 1 2 8 0 0 0
GP140710-90 1 2 2 1 1 41 0 - -
JC070710-77 1 2 3 2 2 28 0 - 0
RM150610-98 0 - 2 0 0 - 0 - 0
MJ240510-23 0 - 3 0 0 - 0 - 1
EC070710-73 0 - 2 0 0 - 0 - -
DD170510-9 0 - 3 0 0 - 0 - 0
FN280610-62 0 - 2 0 0 - 0 - 0
AM140610-50 0 - 2 0 0 - 0 - 1
KG170510-4 0 - 1 0 0 - 0 - 1
AD130710-83 0 - 2 0 0 - 0 - 0
AT090610-45 0 - 1 0 0 - 0 - 0
GN280710-107 0 - 2 0 0 - 0 - -
MB140610-51 0 - 3 0 0 - 0 - 0
JM130710-82 0 - 0 1 1 6 0 - -

1 Histological diagnosis: 0 = tumor-free epithelium, 1 = ESCC, 2 = dysplastic epithelium; 2 Ki-67 index: 0 ≤ 10%: negative, 1 = 10–20%: weakly positive, 2 = 20–50%: positive, 3 ≥ 50%: strongly positive; 3 p16INK4a staining pattern: 0 = focal staining, 1 = diffuse cytoplasmatic positive, 2 = diffuse nuclear positive; 4 p16INK4a staining in tumor tissue: 0 = p16INK4a negative, 1 = 20–50% positive, 2 ≥ 50% strong positive; 5 HPV in PCR: 0 = negative, 1 = positive; 6 In situ hybridization: 0 = negative; 7 HIV status: 0 = negative, 1 = positive; - not done/not evaluable.