Table 1.
The causative agents of ocular microbial infections, antimicrobial treatments, route and duration of administration.
Microbial Infections | Species | Infections | Antimicrobial Treatments | Route of Administration | Duration of Administration | Reference |
---|---|---|---|---|---|---|
Fungal Infections | Candida albicans | chorioretinitis | caspofungin, micafungin, or anidulafungin | Intravenous or oral | Approximate 1 month | [7] |
Aspergillus fumigatus | retinitis, invasive aspergillosis | voriconazole, or posaconazole | Intravenous or oral | - | [7,33,87,88] | |
Cryptococcus neoformans | multifocal chorioretinitis | flucytosine and amphotericin B | Intravenous or oral | - | [84,85] | |
Histoplasma capsulatum | histoplasmosis, retinitis | Laser cauterization | - | Repeated | [2,64] | |
Viral Infections | CMV | retinitis | ganciclovir | Intravenous, intravitreous | >3 weeks | [21] |
foscarnet | Intravenous | - | [57] | |||
cidofovir | Intravenous | - | [62] | |||
fomivirsen | Intravenous | - | [89] | |||
VZV, HZV, HSV types 1 and 2 | ARN, PORN | acyclovir | Intravenous | 7–12 weeks | [62,67] | |
foscarnet | Intravitreal | - | [20] | |||
valaciclovir | Oral | - | [62,90] | |||
famciclovir | Oral | - | [62,91] | |||
Parasitic Infections | Toxocara canis, Toxocara cati | ocular toxocariasis | albendazole or thiabendazole | - | - | [37,38,92] |
Toxoplasma gondii | ocular toxoplasmosis | pyrimethamine-sulfadiazine, trimethoprim-sulfamethoxazole or pyrimethamine-azithromycin | - | - | [93,94,95] | |
Bacterial Infections | Enterococci, Streptococci, Bacilli, gram-negative bacteria | retinitis | vancomycin-amikacin or vancomycin-ceftazidime | - | - | [45,96] |
Treponema pallidum | ocular syphilis | penicillin | Intravenous | 14 days | [58,97,98] | |
ceftriaxone or doxycycline | Parenteral | 3 weeks | [66,98] | |||
Mycobacterium tuberculosis | tubercular retinal vasculitis | isoniazid, rifampin and pyrazinamide, with or without ethambutol | - | Up to 9 months | [65] | |
streptomycin, capreomycin, or quinolones | - | - | [99] |