Table 2.

miRNAs with potential diagnosis value for MPM reported by at least 2 independent studies.

miRNA	Number of Studies	Sample Source	Comparative Analysis Design	References
miR-200c↓	2	Pleural tissue	(1) MPM vs. AD. (2) MPM vs. epithelial carcinoma	[59,60]
miR-126↓	3	Pleural tissue	(1) MPM vs. normal pleura. (2) MPM vs. normal pleura (with Cth). (3) MPM vs. benign/reactive pleurae	[29,66,69]
miR-145↓	3	Pleural tissue	(1) MPM vs. benign pleural tissue. (2) MPM vs. normal pleura. (3) MPM vs. normal pleura (with Cth)	[64,65,66]
miR-16↓	2	Pleural tissue	(1) MPM vs. pericardial tissues. (2) MPM vs. normal pleural tissue	[63,74]
miR-103↓	2	Cellular fraction of peripheral blood	Two subsequent studies: MPM vs. asbestos-exposed controls	[71,72]
miR-126↓	3	Serum	Three subsequent studies: (a) MPM vs. asbestos-exposed controls vs. healthy controls. (b) MPM vs. Healthy controls. (c) MPM vs. asbestos-exposed controls vs. healthy controls	[29,73,85]

Only validated miRNAs (RT-qPCR) are included in this list. ↑ = upregulated expression; ↓ = downregulated expression.