Figure 8.

Schematic diagram of the pathogenic pathway of AD in APP/PS1 transgenic mice and the effects of HE-A and HE-S. This schematic diagram summarize the potential pathogenic pathway of AD in APP/PS1 transgenic mice. Altered APP processing cause Aβ accumulation, oligomerization (oAβ) and plaque core formation (ThS-P). Plaque can grow overtime with the large, diffuse Aβ positive plaque ring-like structure (AB10-P). There is a putative balance between oAβ and AB10-P, both of which may leading to neuroinflammation. Neuroinflammation reduce hippocampal neurogenesis and lead to the behavior deficits. The pathway affected by HE-A only and both HE-A and HE-S are indicated in green and red color, respectively. On behavior tests, only the effect of HE-A was examined (in purple).