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The figure schematically depicts the epithelial cells (endometrial cells) losing their polarity and cell to cell adhesion undergoing changes to assume a migratory mesenchymal cell phenotype. miR-20a and miR-200 play a crucial role in this epithelial mesenchymal transition (EMT) which also is proposed to be one of the key processes in the pathogenesis of endometriosis. ↓ indicates down-regulation and ↑ indicates up-regulation.
