Table 1.
Estrogen receptor (ER) and aromatase expression in stromal and immune cells in the tumor microenvironment.
| TME Cell Type | Cancer Type | Human Expression | Murine Expression | Method of Evaluation | Reference |
|---|---|---|---|---|---|
| Stromal | Breast | Aromatase | ERα | PCR, IHC | [46,47] |
| Melanoma | ERα | IHC | [47] | ||
| Lung | ERα | IHC | [47] | ||
| Endometrial | Aromatase | IHC | [48] | ||
| CAF | Breast | ERα | PCR | [49] | |
| Prostate | ERα, ERβ | IHC | [50,51] | ||
| Endometrial | ERα, ERβ | PCR | [52] | ||
| Ovarian | ERα | IHC | [53] | ||
| TAM | Ovarian | ERα, ERβ | IF, IHC | [54] | |
| Breast | Aromatase | IHC, PCR | [55] | ||
| Lung | Aromatase | Aromatase | IHC | [56,57] | |
| MDSC | Ovarian | ERα | ERα | PCR, Western | [53] |
Studies were identified by PubMed searches using keywords: ERα, ERβ, aromatase, stromal, CAF, TAM, MDSC, expression, cancer. CAF: cancer associated fibroblast; TAM: tumor associated macrophage; MDSC: myeloid derived suppressor cell; IHC: immunohistochemistry; PCR: polymerase chain reaction; IF: immunofluorescence; Western: western blotting analysis.