Table 1.
Genes and enzymes involved in a-series ganglioside biosynthesis. Only steps beyond LacCer are shown.
| Gene | Enzyme | Alternative Names | Synthesis Step |
|---|---|---|---|
| ST3Gal5 | Lactosylceramide sialyltransferase | GM3 synthase, Sial-T1 | LacCer to GM3 |
| B4GalNT1 | GM3 N-acetyl-galactosaminyl transferase | GM2 synthase, GalNAc-T, GM3 sialyltransferase | GM3 to GM2 |
| B3GalT-4 | GM2 galactosyltransferase | GM1 synthase, Gal-T2 | GM2 to GM1 |
| ST3Gal2 | GM1 sialyltransferase | GD1a synthase, Sial-T4 | GM1 to GD1a |
| ST3Gal3 | GD1a sialyltransferase | GT1a synthase, Sial-T5 | GD1a to GT1a |