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. 2018 Feb 23;19(2):634. doi: 10.3390/ijms19020634

Figure 3.

Figure 3

Effect of a 50% decrease in fully-activated conductance (gNa) and a 1.0–1.5% persistent current (Ipst) as observed for the 1795insD mutation in SCN5A on the electrical activity of the Fabbri–Severi model cell at normal beating rate (normal autonomic tone). (A) Membrane potential (Vm). (B) Net membrane current (Inet). (C) Fast sodium current (INa). (D) Persistent component of the fast sodium current (Ipst). Effect of the reduced gNa per se (blue traces), the persistent INa per se (red traces), and the combined effect (green traces). In the model, INa is split into a wild-type and a mutant component, thus representing the effect of a heterozygous mutation.