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. 2018 Feb 24;19(2):640. doi: 10.3390/ijms19020640

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Schematic diagram and amino acid sequences of mouse PCSK9. The full-length PCSK9 is shown (amino acids 1–692). The signal peptide (SP) is located at residues 1–30, the prodomain is at residues 31–151, the catalytic domain is at residues 152–452, and the Cys-His rich domain is at residues 453–692. The amino acid sequence of the catalytic domains is shown (aa 152–452); all Cysteines (C) are marked in red. (B) The amino acid sequence of region-1 of the mPCSK9 (aa 152–251) contains four Cysteines and should yield three different disulfide isomers as predicted. The theoretical molecular weight is 21,201.86 Da. All Cysteines (C) are marked in red. (C) The amino acid sequence of region-2 of the mPCSK9 (aa 249–452) contains six Cysteines and should yield fifteen different disulfide isomers as predicted. The theoretical molecular weight is 21,342.56 Da. All Cysteines (C) are marked in red.

(A) Schematic diagram and amino acid sequences of mouse PCSK9. The full-length PCSK9 is shown (amino acids 1–692). The signal peptide (SP) is located at residues 1–30, the prodomain is at residues 31–151, the catalytic domain is at residues 152–452, and the Cys-His rich domain is at residues 453–692. The amino acid sequence of the catalytic domains is shown (aa 152–452); all Cysteines (C) are marked in red. (B) The amino acid sequence of region-1 of the mPCSK9 (aa 152–251) contains four Cysteines and should yield three different disulfide isomers as predicted. The theoretical molecular weight is 21,201.86 Da. All Cysteines (C) are marked in red. (C) The amino acid sequence of region-2 of the mPCSK9 (aa 249–452) contains six Cysteines and should yield fifteen different disulfide isomers as predicted. The theoretical molecular weight is 21,342.56 Da. All Cysteines (C) are marked in red.