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. 2018 Apr;24(4):486–498. doi: 10.1261/rna.062703.117

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© 2018 Zhang et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 5. — TAT-BIND dose-dependently improved the climbing ability and extended the lifespan of DsRed_CAG250 Drosophila. (A) TAT-BIND treatment during third instar larval stage rescued the climbing defects of adult DsRed_CAG250 Drosophila, whereas TAT-BIND-S had no effect. (B) TAT-BIND treatment during third instar larval stage rescued the climbing defects of adult DsRed_CAG250 Drosophila in a dose-dependent manner. (C) TAT-BIND treatment during adult stage rescued the climbing defects of adult DsRed_CAG250 Drosophila in a dose-dependent manner. (D) TAT-BIND treatment extended the lifespan of DsRed_CAG250 Drosophila in a dose-dependent manner. (E) Area under the curve (AUC) analysis of panel D. For TAT-BIND treatment during larval stage, third instar larvae were treated with respective peptides dissolved in 2% sucrose solution for 2 h at room temperature. For TAT-BIND treatment during adult stage, adult flies were starved for 8 h followed by overnight feeding with respective peptides in 2% sucrose solution at room temperature. The genotypes of flies were: elav-GAL4; +/+; UAS-DsRed_CAG250/+. Data are plotted as mean ± SEM and were from at least six independent experiments. (*) P < 0.05, (**) P < 0.01, (***) P < 0.001. NS, no significant difference.