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. 2018 Apr;24(4):486–498. doi: 10.1261/rna.062703.117

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© 2018 Zhang et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 7. — Specificity and cytotoxicity study of BIND. (A) TAT-BIND did not suppress the neurodegeneration of CTG480- and CGG90-expressing fly eyes. Third instar larvae were treated with respective peptides dissolved in 2% sucrose solution for 2 h at room temperature. External eye pictures of 1 dpe CTG480 and 2 dpe CGG90 Drosophila were captured. The genotypes of flies were: w; gmr-GAL4/+; UAS-CTG480/+ and w; gmr-GAL4 UAS-EGFP-CGG90/+; +/+. (B) TAT-BIND did not exert toxic effects on primary rat cortical neurons. Data were normalized to untreated control and are plotted as mean ± SEM. All the experiments were repeated at least three times. NS, no significant difference.