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. 2018 Apr;24(4):513–528. doi: 10.1261/rna.064469.117

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© 2018 Lackey et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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FIGURE 1. — Variation within LCP1 and TPT1. (A) LCP1 mRNA is long (coding sequence of 1884 nt) and is composed of 16 exons. (B) TPT1 has three isoforms and multiple alternative polyadenylation sites, of which NM_003295 with an early polyadenylation site is the most prevalent (∼1000 nt in length). All identified inherited SNVs and somatic mutations within these genes are shown (blue, nonsynonymous; gold, synonymous). We tested all synonymous somatic mutations within the LCP1 and TPT1 CDS regions and selected inherited variants.