Fig. 5.

The effects of prior lymphadenectomies on the development of mechanical allodynia after adult rat mSNIs. a Schematic illustration of prior lymphadenectomies to the local lymph nodes along the somatosensory pathways 7 days before mSNIs on the right hindlimbs, and VFH behavioral testing for mechanical allodynia on the glabrous sural skin areas, i.e., the lateral plantar surfaces of the hindpaws. b–e Temporal dynamics of 50% PWTs (g) for both ipsilateral (ipsi) and contralateral (contra) hindpaws before and after mSNIs in lymphadenectomized or sham-operated animals to LLNs (b; n = 9/group), CLNs (c; n = 6/group), SLNs (d; n = 6/group), and PLNs (e; n = 6/group). ^**P < 0.01; ^***P < 0.001; lymphadenectomy versus sham operation for ipsilateral hindpaws. CLN cervical lymph node, LLN lumbar lymph node, mSNI modified spared nerve injury, PLN popliteal lymph node, PWT paw withdrawal threshold, SLN sciatic lymph node, SN sciatic nerve, VFH von Frey hair