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. 2018 Mar 12;13:1457–1470. doi: 10.2147/IJN.S155814

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© 2018 Shi et al. This work is published and licensed by Dove Medical Press Limited

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HAPs induce osteogenic differentiation of hWJ-MSCs via activation of JNK and p38 signaling pathways. (A) The expression profile of key proteins in JNK and p38 signaling pathways in hWJ-MSCs cultured with np20, np80, and m-HAP for 24 h. (B) The extracellular calcium deposition in hWJ-MSCs cultured in HAPs for 14 days with or without SP600125 and SB203580, respectively. Cells without HAPs treatment were set as the control group.

Abbreviations: HAPs, hydroxyapatite particles; hWJ-MSCs, human umbilical cord Wharton’s jelly-derived mesenchymal stem cells; JNK, c-Jun N-terminal kinases; np20, hydroxyapatite nanoparticles 20 nm in diameter; np80, hydroxyapatite nanoparticles 80 nm in diameter; m-HAP, micro-sized HAP particles; HAP, hydroxyapatite.