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. 2018 Mar 12;13:1457–1470. doi: 10.2147/IJN.S155814

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© 2018 Shi et al. This work is published and licensed by Dove Medical Press Limited

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The role of different endocytic pathways in HAPs uptake in hWJ-MSCs. Cells were exposed to HAPs with or without cpz, mβcd, and cytoD, respectively. (A) CLSM images of hWJ-MSCs exposed to HAPs for 2 h. Cells stained for nuclei (blue) and actin (red). HAPs are shown in green color. Scale bars: 50 μm. (B) Quantification of HAPs uptake after hWJ-MSCs were treated with HAPs for 2 h. *P<0.01 versus no inhibitor control, ^&P<0.05; ^&&P<0.01 versus m-HAP group, ^#P<0.01 versus np20 group.

Abbreviations: HAPs, hydroxyapatite particles; hWJ-MSCs, human umbilical cord Wharton’s jelly-derived mesenchymal stem cells; cpz, chlorpromazine; mβcd, methyl-β-cyclodextrin; cytoD, cytochalasin D; CLSM, confocal laser scanning microscopy; np20, hydroxyapatite nanoparticles 20 nm in diameter; np80, hydroxyapatite nanoparticles 80 nm in diameter; m-HAP, micro-sized HAP particles; HAP, hydroxyapatite.