Table S1.
Search strategy
| No | Searches |
|---|---|
| 1 | Clostridium difficile/ |
| 2 | exp Enterocolitis, Pseudomembranous/ |
| 3 | exp Clostridium Infections/ |
| 4 | (((clostridium or clostridial) adj3 (enterocolitis or enteritis or colitis or disease* or infection* or diarrhea or diarrhoea)) or “antibiotic associated colitis” or “bacillus difficilis” or “C difficile” or CDAD or clostridioses or clostridiosis or “clostridium difficile” or “clostridium difficilis” or “pseudomembranous colitis” or “pseudomembranous enteritis” or “pseudomembranous enterocolitis”).mp. |
| 5 | 1 or 2 or 3 or 4 |
| 6 | exp Hydroxymethylglutaryl-CoA Reductase Inhibitors/or statins.mp. |
| 7 | (“hmg coa” or ((hydroxymethylglutaryl or hmg) adj (coa or coenzyme)) or atorvastatin or cerivastatin or compactin or fluindostatin or lovastatin or mevinolin* or pitavastatin or pravastatin or rosuvastatin or simvastatin).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading]. |
| 8 | exp hydroxymethylglutaryl coenzyme A reductase inhibitor/ |
| 9 | or/6-8 |
| 10 | 6 or 7 or 8 or 9 |
| 11 | exp survival/ |
| 12 | exp death/ |
| 13 | exp mortality/ |
| 14 | mortality.fs. |
| 16 | exp survival analysis/ |
| 17 | exp evidence based medicine/ |
| 18 | exp meta analysis/ |
| 19 | exp Meta-Analysis as Topic/ |
| 20 | exp “systematic review”/ |
| 21 | exp Guideline/or exp Practice Guideline/ |
| 22 | exp controlled study/ |
| 23 | exp Randomized Controlled Trial/ |
| 24 | exp triple blind procedure/ |
| 25 | exp Double-Blind Method/ |
| 26 | exp Single-Blind Method/ |
| 27 | exp latin square design/ |
| 28 | exp comparative study/ |
| 29 | exp intervention studies/ |
| 30 | exp Cross-Sectional Studies/ |
| 31 | exp Cross-Over Studies/ |
| 32 | exp Cohort Studies/ |
| 33 | exp longitudinal study/ |
| 34 | exp retrospective study/ |
| 35 | exp prospective study/ |
| 36 | exp clinical trial/ |
| 37 | clinical study/ |
| 38 | exp case–control studies/ |
| 39 | exp confidence interval/ |
| 40 | exp multivariate analysis/ |
| 41 | ((evidence adj based) or (meta adj analys*) or (systematic* adj3 review*) or guideline* or (control* adj3 study) or (control* adj3 trial) or (randomized adj3 study) or (randomized adj3 trial) or (randomised adj3 study) or (randomised adj3 trial) or “pragmatic clinical trial” or (doubl* adj blind*) or (doubl* adj mask*) or (singl* adj blind*) or (singl* adj mask*) or (tripl* adj blind*) or (tripl* adj mask*) or (trebl* adj blind*) or (trebl* adj mask*) or “latin square” or placebo* or nocebo* or multivariate or “comparative study” or “comparative survey” or “comparative analysis” or (intervention* adj2 study) or (intervention* adj2 trial) or “cross-sectional study” or “cross-sectional analysis” or “cross-sectional survey” or “cross-sectional design” or “prevalence study” or “prevalence analysis” or “prevalence survey” or “disease frequency study” or “disease frequency analysis” or “disease frequency survey” or crossover or “cross-over” or cohort* or “longitudinal study” or “longitudinal survey” or “longitudinal analysis” or “longitudinal evaluation” or longitudinal* or ((retrospective or “ex post facto”) adj3 (study or survey or analysis or design)) or retrospectiv* or “prospective study” or “prospective survey” or “prospective analysis” or prospectiv* or “concurrent study” or “concurrent survey” or “concurrent analysis” or “clinical study” or “clinical trial” or “case control study” or “case base study” or “case referrent study” or “case referent study” or “case referent study” or “case compeer study” or “case comparison study” or “matched case control” or “multicenter study” or “multi-center study” or “odds ratio” or “confidence interval” or “change analysis” or ((study or trial or random* or control*) and compar*)).mp,pt. |
| 42 | (clinical trial, all or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or clinical trial or controlled clinical trial or multicenter study or observational study or randomized controlled trial or pragmatic clinical trial or comparative study or controlled clinical trial or guideline or practice guideline or meta analysis or multicenter study or observational study or randomized controlled trial or pragmatic clinical trial or systematic reviews) [Limit not valid in Embase,CCTR,CDSR; records were retained] |
| 43 | (editorial or erratum or letter or note or addresses or autobiography or bibliography or biography or comment or dictionary or directory or interactive tutorial or interview or lectures or legal cases or legislation or news or newspaper article or overall or patient education handout or periodical index or portraits or published erratum or video-audio media or webcasts) [Limit not valid in Embase,Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process,CCTR,CDSR; records were retained] |
| 44 | limit to English language [Limit not valid in CDSR; records were retained] |