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. 2018 Feb 15;18(2):599. doi: 10.3390/s18020599

Table 4.

PDA vesicles for detection of viruses.

Composition of the Bilayer Diameter of Vesicles Type of Transduction Type of Virus Virus LOD Reference
95% PCDA/5% sialic acid derivatized PCDA colorimetry Influenza 11 × 107 virus particles [55]
95% PCDA/5% sialic acid derivatized PCDA colorimetry Influenza 8 × 107 virus particles [56]
PCDA/5% S-sialo PCDA colorimetry Influenza X-31 0.78 HAU [57]
PDMA/DMPC/G1/G2
G1: sialic acid-β-glucoside
G2: lactose-β-glucoside
10–20 nm colorimetry H5N1 Avian influenza 10 ng/mL hemagglutinin [58]
PCDA
Anti-H5N1 monoclonal antibody grafted on vesicle surface
117 nm colorimetry
fluorescence
H5N1 Avian influenza 30 ng/mL HAQ
1 ng/mL HAQ
[59]
PCDA/DMPC
Anti-HA monoclonal antibody grafted on vesicle surface
colorimetry H5 influenza 0.53 copies/µL [60]
PEP-PCDA ~50 nm colorimetry H1N1 influenza 105 PFU [61]

DMPC: dimyristoylphosphatidylcholine; HAQ: target antigen of H5N1 Avian influenza virus strain; LOD: limit of detection; PCDA: 10,12-pentacosadiynoic acid; PEP-PCDA: peptide-functionalized 10,12-pentacosadiynoic acid.