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APP and Aβ might impair neurogenesis in APP/PS1KI mice. Abundant APP immunoreactivity in granule cells of the dentate gyrus and plaque-associated dystrophic neurites in 6-month-old APP/PS1KI mice (A). Aβ staining is mainly restricted to extracellular deposits in an adjacent section (B). Doublecortin (DCX)-immunoreactivity is almost lacking in APP/PS1KI mice (C), but clearly detectable in an age-matched wildtype animal (D).
