Table 1.

Selection of different AD and DS mouse models in which impaired neurogenesis has been reported.

Transgenic mouse model	Mutation APP	Mutation PS1	Promoter	Plaque onset	Neuron loss	Neuro-genesis	Effect of PA/EE on NG	Reference
Tg2576	Swedish	–	Hamster Prion Protein	12m	no	↓	↑	23,16
3xTg-AD	Swedish	M146V	Thy1 (APP, Tau)	6m	n.a.	↓	↑	17,24
			PS1 knock-in
APP751SL/PS1KI	Swedish, London	M233T, L235P	Thy1 (APP)	2m	✓(6m)	↓	⇆	18,25,32,33
			PS1 knock-in
Tg4–42	–	–	Thy1 (Aβ4–42)	–	✓(5m)	n.a.	↑	26,35
TTA/APP	Swedish, Indiana	–	CaMKIIα-TTA	< 6m	n.a.	⇆	n.a.	27
APP-wt	–	–	PDGF	–	n.a	↓	↑	37
Ts65Dn	trisomic	–	–	–	n.a.	↓	↑	42,41