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. Author manuscript; available in PMC: 2019 Jan 24.
Published in final edited form as: J Am Chem Soc. 2018 Jan 9;140(3):876–879. doi: 10.1021/jacs.7b11704

Figure 3.

Figure 3

Congo red, but not related azo dyes, inhibits LtaS in vitro and against WTA-deficient S. aureus strains. (A) 1 inhibits in vitro LTA polymerization in proteoliposomes in a dose-dependent manner. (B) Structures of azo dyes tested against S. aureus strains and proteoliposomes. (C) Replicate dot blots of assays containing the indicated concentrations of 1 and 2 (for 3, 4, and 1771, see Figure S8). (D) 1 selectively inhibited the growth of a Newman ΔtarO strain, but not Newman (Figure S9).