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. Author manuscript; available in PMC: 2018 Mar 16.
Published in final edited form as: Cell Rep. 2018 Feb 27;22(9):2246–2253. doi: 10.1016/j.celrep.2018.02.026

Figure 1. SynDIG4 Modifies AMPAR Gating Kinetics in a Subunit-Dependent Manner.

Figure 1

(A and B) Representative normalized current responses of AMPAR recorded upon 1 ms (A) and 500 ms (B) application of 10 mM glutamate (G, indicated above the current trace) to giant outside-out patches excised from Xenopus laevis oocytes expressing homomeric GluA1 (top) and heteromeric GluA1/2 (bottom) alone (black) or in combination with SynDIG4 (red), TARPγ8 (green), or both (blue). Graphs summarize weighted time constants for deactivation (τW deact) and desensitization (τW des), as well as steady-state to peak current (ss/peak). Data shown are mean ± SEM; n = 10–20 patches.

Significance (one-way ANOVA): */$ p < 0.05; **/$$ p < 0.01; ***/$$$ p < 0.001; ns, not significant. See also Table S1.