Table 3.

Inhibitory effect of indomethacin on plasma electrolyte level induced by EFPA in rats

Groups	Plasma levels (mEq/L)
	Na+	Cl−	K+	Ca2+
Control	114.70 ± 5.51	104.33 ± 3.90	70.50 ± 2.90	5.40 ± 2.52
EFPA (10 mg/kg)	125.50 ± 4.00	102.00 ± 4.32	54.70 ± 2.80*	5.21 ± 2.60
EFPA (10 mg/kg) + Indomethacin (5 mg/kg)	119.33 ± 4.43	103.33 ± 3.41	50.83 ± 5.10*	5.13 ± 2.54

Rats were treated over a 24 h period with a single dose of either vehicle (control group), EFPA (10 mg/kg) or EFPA (10 mg/kg) + indomethacin (5 mg/kg, 1 h pretreatment) administered i.p. Data are given as means ± SEM of 6 different experiments. Statistical analyses were assessed using two-way analysis of variance (ANOVA) followed by Bonferroni’s post- test. *p < 0.05 versus control, and ^#p < 0.05 versus EFPA