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. 2018 Mar 15;18:293. doi: 10.1186/s12885-018-4133-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — 3-D model of GαS. Residues 40 to 394 of Gαs are represented based on protein model portal, template 3sn6A. The GTP binding domains are indicated in yellow, the most common gsp mutations, at R201 (the target of Cholera toxin) and Q227, are indicated in red