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. 2018 Mar 15;18:293. doi: 10.1186/s12885-018-4133-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — GPCR dependent production of intracellular cAMP determines secretory function in specialized cells of different exocrine organs. Among GPCRs determinant for the differentiation and function of tissues displaying the gsp+ phenotype, are secretin family receptors (glucagon, GIP, secretin, VIP, GHRH) and LGR receptors (LGR 1-8). The same pathways instrumental to zonation and differentiation are also likely acting on transcriptional programs related to the differentiation stage reached by the cells. NR5A master regulators are present in cells displaying the gsp+ phenotype (thyroid [95], osteoblast [93], somatotropic, pancreatic cells [98], hepatocytes, intestinal crypt [91], adrenocortical, Leydig and granulosa cells [99])