Table 3.
Logistic regression of distributions and genetic models of each SNP’s genotype of CDKAL1 and CDKN2A/B
| GDM, n (%) | None GDM, n (%) | P value | OR (95% CI) | ||
|---|---|---|---|---|---|
| rs7754840 (CDKAL1) | |||||
| Co-dominant model | G/G | 3 (6.4) | 8 (15.7) | 1 | |
| C/G | 26 (55.3) | 23 (45.1) | 0.122 | 3.014 (0.714–12.731) | |
| C/C | 18 (38.3) | 20 (39.2) | 0.236 | 2.400 (0.551–10.457) | |
| Dominant model | CG + CC | 44 (93.6) | 43 (84.3) | 0.145 | 2.729 (0.678–10.976) |
| GG | 3 (6.4) | 8 (15.7) | 1 | ||
| Recessive model | CC | 18 (38.3) | 20 (39.2) | 0.926 | 0.962 (0.426–2.170) |
| GG + CG | 29 (61.7) | 31 (60.8) | 1 | ||
| Over-dominant model | CG | 26 (55.3) | 23 (45.1) | 0.312 | 1.507 (0.679–3.344) |
| GG + CC | 21 (44.7) | 28 (54.9) | 1 | ||
| rs10811661(CDKN2A/B) | |||||
| Co-dominant model | CC | 38 (80.9) | 38 (74.5) | 1 | |
| CT | 7 (14.9) | 10 (19.6) | 0.510 | 0.700 (0.241–2.031) | |
| TT | 2 (4.3) | 3 (5.9) | 0.665 | 0.667 (0.105–4.218) | |
| Dominant model | CT + TT | 9 (19.1) | 13 (25.5) | 0.452 | 0.692 (0.265–1.811) |
| CC | 38 (80.9) | 38 (74.5) | 1 | ||
| Recessive model | TT | 2 (4.3) | 3 (5.9) | 0.715 | 0.711 (0.114–4.454) |
| CC + CT | 45 (95.7) | 48 (94.1) | 1 | ||
| Over-dominant model | CT | 7 (14.9) | 10 (19.6) | 0.538 | 0.718 (0.249–2.070) |
| CC + TT | 40 (85.1) | 41 (80.4) | 1 | ||