Table 3. Primary Outcome, According to Cycle-Threshold Value and Age.*.
| Age and Cycle-Threshold Value | Convalescent Plasma (N = 84) |
Control (N = 418) |
||
|---|---|---|---|---|
| Patients | Death | Patients | Death | |
| no. (%) | no./total no. (%) | no. (%) | no./total no. (%) | |
| All ages | ||||
| <25 cycles | 21 (25) | 11/21 (52) | 159 (38) | 90/159 (57) |
| 25–29.9 cycles | 41 (49) | 11/41 (27) | 183 (44) | 56/183 (31) |
| ≥30 cycles | 22 (26) | 4/22 (18) | 76 (18) | 12/76 (16) |
| Age <5 yr | 5 (6) | 1/5 (20) | 23 (6) | 15/23 (65) |
| <25 cycles | 1 (1) | 1/1 (100) | 12 (3) | 10/12 (83) |
| 25–29.9 cycles | 3 (4) | 0 | 10 (2) | 5/10 (50) |
| ≥30 cycles | 1 (1) | 0 | 1 (<1) | 0 |
| Age 5–15 yr | 8 (10) | 1/8 (12) | 53 (13) | 10/53 (19) |
| <25 cycles | 2 (2) | 0 | 19 (5) | 5/19 (26) |
| 25–29.9 cycles | 3 (4) | 1/3 (33) | 23 (6) | 3/23 (13) |
| ≥30 cycles | 3 (4) | 0 | 11 (3) | 2/11 (18) |
| Age 16–44 yr | 56 (67) | 16/56 (29) | 258 (62) | 90/258 (35) |
| <25 cycles | 15 (18) | 8/15 (53) | 97 (23) | 50/97 (52) |
| 25–29.9 cycles | 28 (33) | 5/28 (18) | 112 (27) | 34/112 (30) |
| ≥30 cycles | 13 (15) | 3/13 (23) | 49 (12) | 6/49 (12) |
| Age ≥45 yr | 15 (18) | 8/15 (53) | 84 (20) | 43/84 (51) |
| <25 cycles | 3 (4) | 2/3 (67) | 31 (7) | 25/31 (81) |
| 25–29.9 cycles | 7 (8) | 5/7 (71) | 38 (9) | 14/38 (37) |
| ≥30 cycles | 5 (6) | 1/5 (20) | 15 (4) | 4/15 (27) |
*
Each RT-PCR assay provided a cycle-threshold value, which is the number of cycles required for the fluorescent signal to cross the threshold for a positive test. A lower value is correlated with a higher viral load.