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. 2018 Mar 16;11:11. doi: 10.1186/s13072-018-0181-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Additivity of the effect of multiple PTMs. Shown are the relative changes in free energy for different combinations of PTMs (∆∆G¹⁺²) compared to the sum of individual PTMs (∆∆G¹ + ∆∆G²). In rare cases (two outlier blue crosses), the change in ∆∆G¹⁺² due to a pair of PTMs can be significantly different from the sum of the changes in binding affinity for each of the PTMs separately (∆∆G¹ + ∆∆G²). The green dot identifies the PTM pair for which experimental data are available, [43], and the red star shows the corresponding predicted value