Table 1. Clinical manifestations of investigational findings in Ebola virus disease, reported by studies done during the west Africa epidemic.

	Signs and symptoms13 reported in more than 10% of patients with acute Ebola virus disease	Investigational findings that have been reported during acute Ebola virus disease	Signs and symptoms during survivor syndrome from Ebola virus disease
General	Fever, fatigue, hiccups	Raised pro-inflammatory markers, including CRP; elevated lactate34	Fatigue,35–37 depression,36–39 anxiety,36,37,39 insomnia35,36,38
Neurological and visual	Headache, confusion	Detectable Ebola virus RNA in the cerebrospinal fluid;40,41 diffuse swelling, microvascular occlusions as observed by MRI42	Difficulty concentrating, mood changes, and memory loss;38,39 headaches;35,36,38,43 dizziness;38 difficulties hearing;35,37–39,44 visual disturbances;35–37,39,43,44 peripheral paraesthesia or dysaethesia37
Cardiovascular	Chest pain	Bradycardia,45 arrhythmias as shown by electrocardiogram;46 myocarditis shown during MRI47	Chest pain,36,38,43 palpitations35,37,38
Pulmonary	Cough, dyspnoea, sore throat	Pulmonary oedema and pulmonary effusion as observed on x-ray and USS46	Dyspnoea37
Gastrointestinal	Anorexia, vomiting, diarrhoea, abdominal pain, odynophagia	Paralytic ileus and bowel wall oedema shown by USS29,48	Anorexia,35,38 abdominal pain,35,36,38,43 constipation38
Hepatobiliary	Jaundice	Transaminitis with high AST:ALT ratio34,49	··
Renal, urological, and electrolytes	··	Acute kidney injury,34,50,51 raised creatine kinase,34 hypokalaemia34,49,51 or hyperkalaemia,34 hyponatraemia,34 hypocalcaemia,49 hypoglycaemia16	Decreased libido; sexual dysfunction and testicular pain36,38
Haematological	Clinically significant haemorrhage uncommon, likely to be more frequent in pregnant women.	Leucopenia, thrombocytopenia, raised INR, haematoconcentration34	Anaemia35
Skin and musculoskeletal	Myalgia, arthralgia, conjunctivitis	··	Arthralgia;35,36,39,43,44 myalgia;36 alopecia, skin peeling, and pruritus35,36,38,39,43

USS=ultrasound scan. ALT=alanine transaminase. AST=aspartate transaminase. CRP=C-reactive protein. INR=international normalised ratio.