Fig. 1.

Viperin controls virus replication in the olfactory bulb. Survival analysis and viral burdens of LGTV infected WT and viperin^−/− mice after intraperitoneal inoculation. a Survival analysis of 6- to 8-week-old WT and vipeirn^−/− mice after inoculation of 10⁴ FFU of LGTV by intraperitoneal route (n = 10). Survival differences were tested for statistical significance by log-rank test. b–h Viral burdens in different organs (lung, spleen, spinal cord, olfactory bulb, cerebrum, cerebellum, and brain stem) of WT and Viperin^−/− mice after intraperitoneal infection of LGTV (10⁴ FFU, n = 5) measured by qPCR detecting LGTV NS3 gene (detection limit 10 copies) and normalized to intracellular GAPDH levels. Each data point represents an individual mouse. Bars indicated mean values. Asterisks indicate statistical significance calculated by the Mann-Whitney test (*P < 0.05; **P < 0.005). a.u., arbitrary units