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. 2018 Mar 15;15:82. doi: 10.1186/s12974-018-1121-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The acute effect of STZ-induced hyperglycemia on microgliosis and astrocytosis on P6. Representative photomicrographs of the hippocampal CA1 region at 10× stained for CD-11 from a control and b hyperglycemia groups. Scale bars = 250 μm. The number of CD-11-positive microglia was significantly increased in the hyperglycemia group (gray) relative to control (black), *p < 0.05 (c). Representative photomicrographs of the hippocampal CA1 region at 20× stained for S100β astrocytes from d control and e hyperglycemia groups. Scale bars = 100 μm. The number of S100β positive astrocytes was significantly increased in the hyperglycemia group (gray) relative to the control (black), p < 0.05 (f)